Continuous system to fructooligosaccharides production with loofa sponge as na immobilization matrix

Abstract: Fructooligosaccharides (FOS) production is conducted in batch bioreactors, a slow and costly process. Therefore, it is necessary to implement continuous reaction systems in fixed bed reactors (PBR) that increase the volume of FOS production and decrease its operating costs. This work evaluates the transfructosylation activity of Aspergillus oryzae IPT-301 Leia mais…

Chikungunya-driven gene expression linked to osteoclast survival and chronic artharalgia

Abstract: Chikungunya fever (CHIKF), caused by the Chikungunya virus (CHIKV), manifests as acute febrile illness often associated with polyarthritis and polyarthralgia. Although the acute symptoms resolve within two weeks, many patients experience prolonged joint pain and inflammation, resembling rheumatoid arthritis (RA). This study aimed to identify molecular markers related to Leia mais…

Enhancing microfluidic device design for CART-T cell transfection: integrating soft lithography and CFD simulation for optimal microvortex patterns

Referência: ANDREOTTI, Isabela Aparecida de Araujo; GRIEP, Gabriel; PATIÑO-NARIÑO, Edgar A.; OLIVEIRA, Aline Furtado; BEJARANO, Martha Lucia Mora; GONGORA-RUBIO, Mario Ricardo; WISINEWSKI, Henrique Reis; MIRANDA, Beatriz N.M.; SILVA, Leonardo R.B.; VERONA, Bruno M.; BALBINO, Tiago A.; BONAMINO, Martín H. Enhancing microfluidic device design for CART-T cell transfection: integrating soft lithography Leia mais…

HER2 aptamer-conjugated iron oxide nanoparticles with PDMAEMA-b-PMPC coating for breast cancer cell identification

Abstract: To synthesize HER2 aptamer-conjugated iron oxide nanoparticles with a coating of poly(2-(dimethylamino) ethyl methacrylate)–poly(2-methacryloyloxyethylphosphorylcholine) block copolymer (IONPPPs). Characterization covered molecular structure, chemical composition, thermal stability, magnetic characteristics, aptamer interaction, crystalline nature and microscopic features. Subsequent investigations focused on IONPPPs for in vitro cancer cell identification. Results demonstrated high biocompatibility Leia mais…

Coding, decoding and retrieving a message using DNA: na experience from a Brazilian Center Research on DNA Data Storage

Abstract: DNA data storage based on synthetic oligonucleotides is a major attraction due to the possibility of storage over long periods. Nowadays, the quantity of data generated has been growing exponentially, and the storage capacity needs to keep pace with the growth caused by new technologies and globalization. Since DNA Leia mais…

Challenges of encoding digital data into DNA sequences and decoding it back to digital

Referência: MARTINS, Andre Guilherme da Costa. Challenges of encoding digital data into DNA sequences and decoding it back to digital. São Paulo, 2024. (Palestra apresentada na disciplina de Biologia Molecular do Programa de Pós-graduação Multicêntrico em Bioquímica e Biologia Molecular, do Campus Centro-Oeste Dona Lindu-UFSJ) Acesso aos slides da apresentação Leia mais…

Ecotoxicologixal assessment of metformin as an antidiabetic water reside treated by eléctron beam accelerator irradiation

Abstract: Metformin (MET), an antidiabetic compound, has received increasing attention, as it cannot be effectively removed during conventional wastewater treatment processes and may act as an endocrine disruptor. Electron beam irradiation (EBI) is an eco-friendly process able to degrade and neutralize biohazardous pollution almost instantly. In this context, this study Leia mais…

HER2 aptamer-conjugated iron oxide nanoparticles with PDMAEMA-b-PMPC coating for breast cancer cell identification

Abstract: To synthesize HER2 aptamer-conjugated iron oxide nanoparticles with a coating of poly(2-(dimethylamino) ethyl methacrylate)–poly(2-methacryloyloxyethylphosphorylcholine) block copolymer (IONPPPs). Characterization covered molecular structure, chemical composition, thermal stability, magnetic characteristics, aptamer interaction, crystalline nature and microscopic features. Subsequent investigations focused on IONPPPs for in vitro cancer cell identification. Results demonstrated high biocompatibility Leia mais…

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