Bionanomanufatura

Abstract: Severe COVID-19 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID-19. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA-seq samples, and over 2 million single cells. A Leia mais…

Abstract: The immobilization of fructosyltransferase enzymes has been identified as an essential strategy for the production of fructooligosaccharides (FOS) in heterogeneous reaction systems. This study investigated the applicability of silica gel and silica gel functionalized with glutaraldehyde as porous inorganic supports for the immobilization of the extracellular fructosyltransferase from Aspergillus Leia mais…

Abstract: This study investigated the effect of low-cost carbon and nitrogen sources on fructosyltransferase (FTase) production by Aspergillus oryzae IPT-301, aiming to optimize the enzymatic synthesis of fructooligosaccharides (FOS), prebiotic compounds valued for their bifidogenic effects. FTase is a key enzyme in transfructosylation, the central step in FOS production. To Leia mais…

Abstract: MDMA and MDA are among the stimulant drugs most frequently encountered in forensic casework, and oral fluid represents a practical biological matrix for their detection. However, liquid oral fluid requires refrigeration, is susceptible to degradation, and can be logistically demanding for routine laboratories. Dried Oral Fluid Spots (DOFS) offer Leia mais…

Abstract: The COVID-19 pandemic underscored the urgent need for advanced drug delivery systems to enhance the safety and efficacy of existing antiviral therapies. This study presents an inhalable powder formulation of remdesivir (RDV) using polymeric nano-in-microparticles for pulmonary administration. RDV was nanoencapsulated in a polycaprolactone (PCL) matrix via emulsiondiffusion- solvent Leia mais…

Abstract: This study aimed to develop nanoparticles containing polyphenols from Syrah red wine grapes to protect the bioactive compounds and improve their stability and bioavailability. The properties of maltodextrin (MD) and gum arabic (GA), used as encapsulating agents, were evaluated. The coating material formulation was conducted in a completely randomized Leia mais…