Development of a dry poder formulation for pulmonar delivery of azithromycin-loaded nanoparticles

Abstract: The COVID-19 pandemic has raised concern regarding respiratory system diseases and oral inhalation stands out as an attractive non-invasive route of administration for pulmonary diseases such as chronic bronchitis, cystic fibrosis, COVID-19 and community-acquired pneumonia. In this context, we encapsulated azithromycin in polycaprolactone nanoparticles functionalized with phospholipids rich in Leia mais…

Continuous system to fructooligosaccharides production with loofa sponge as na immobilization matrix

Abstract: Fructooligosaccharides (FOS) production is conducted in batch bioreactors, a slow and costly process. Therefore, it is necessary to implement continuous reaction systems in fixed bed reactors (PBR) that increase the volume of FOS production and decrease its operating costs. This work evaluates the transfructosylation activity of Aspergillus oryzae IPT-301 Leia mais…

Chikungunya-driven gene expression linked to osteoclast survival and chronic artharalgia

Abstract: Chikungunya fever (CHIKF), caused by the Chikungunya virus (CHIKV), manifests as acute febrile illness often associated with polyarthritis and polyarthralgia. Although the acute symptoms resolve within two weeks, many patients experience prolonged joint pain and inflammation, resembling rheumatoid arthritis (RA). This study aimed to identify molecular markers related to Leia mais…

Enhancing microfluidic device design for CART-T cell transfection: integrating soft lithography and CFD simulation for optimal microvortex patterns

Referência: ANDREOTTI, Isabela Aparecida de Araujo; GRIEP, Gabriel; PATIÑO-NARIÑO, Edgar A.; OLIVEIRA, Aline Furtado; BEJARANO, Martha Lucia Mora; GONGORA-RUBIO, Mario Ricardo; WISINEWSKI, Henrique Reis; MIRANDA, Beatriz N.M.; SILVA, Leonardo R.B.; VERONA, Bruno M.; BALBINO, Tiago A.; BONAMINO, Martín H. Enhancing microfluidic device design for CART-T cell transfection: integrating soft lithography Leia mais…

HER2 aptamer-conjugated iron oxide nanoparticles with PDMAEMA-b-PMPC coating for breast cancer cell identification

Abstract: To synthesize HER2 aptamer-conjugated iron oxide nanoparticles with a coating of poly(2-(dimethylamino) ethyl methacrylate)–poly(2-methacryloyloxyethylphosphorylcholine) block copolymer (IONPPPs). Characterization covered molecular structure, chemical composition, thermal stability, magnetic characteristics, aptamer interaction, crystalline nature and microscopic features. Subsequent investigations focused on IONPPPs for in vitro cancer cell identification. Results demonstrated high biocompatibility Leia mais…

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