Polymeric nano-in-microparticles for pulmonar delivery of remdesivir agains SARS-CoV-2

Abstract: The COVID-19 pandemic underscored the urgent need for advanced drug delivery systems to enhance the safety and efficacy of existing antiviral therapies. This study presents an inhalable powder formulation of remdesivir (RDV) using polymeric nano-in-microparticles for pulmonary administration. RDV was nanoencapsulated in a polycaprolactone (PCL) matrix via emulsiondiffusion- solvent Leia mais…

A importância da Biblioteca na preservação e disseminação do conhecimento e científico: o caso da GITEB no IPT

Resumo: Este artigo tem como objetivo apresentar a atuação da Biblioteca do Instituto de Pesquisas Tecnológicas do Estado de São Paulo (IPT), formalmente denominada Gerência de Gestão da Informação Tecnológica e Bibliográfica (GITEB). A biblioteca é responsável por apoiar as atividades de pesquisa, desenvolvimento tecnológico, inovação e ensino, oferecendo um Leia mais…

Viscoelastic and mechanical behavior of the thermoset composite interleaved with electrospun polybutadiene

Abstract: This work aims the processing of multifunctional thermoset composites, consisting of carbon fibers/epoxy resin prepreg, and polybutadiene (BR) mats produced via electrospinning process aiming to provide a composite material with high tenacity. Initially, polybutadiene mats were produced by electrospinning. These mats and prepregs materials were hot compressed at eight Leia mais…

Empreendedorismo tecnológico: startup e sustentabilidade no Século XXI

Resumo: O presente artigo trata do papel do empreendedorismo e das startups como vetores de inovação e desenvolvimento sustentável na era contemporânea, marcada pela transformação digital, pela aceleração tecnológica e pela importância de ecossistemas de inovação aberta. A partir de uma abordagem interdisciplinar, o texto apresenta fundamentos conceituais do empreendedorismo Leia mais…

Herbivore-induced specificity and diversity in piper arboreum valatiles

Abstract: The essential oils obtained by steam distillation of leaves of Piper species have found several applications in bioeconomy due to their various biological properties. Nevertheless, the analysis of essential oils does not provide information regarding the ecologically relevant volatile organic compounds (VOCs) emitted by metabolically active leaves under real-world Leia mais…

Phytochemical composition and nematicidal activity of tropical piper species

Abstract: Current research has shown that volatile oils from Piper species exhibit promising biological activities. However, these effects remain underexplored in scientific literature. This study investigated the phytochemical profile and anthelmintic activity of volatile oils from Piper species, as well as their major constituents, against the nematode Caenorhabditis elegans. The Leia mais…

Particulate matter extracted from human anthracotic tissues induces inflammatory markers in co-culture of lung cells and macrophages

Abstract: Anthracosis, characterized by black pigmentation in the lungs and tracheobronchial tree due to inhaled carbon particles, has been linked to urban air pollution. This study analyzed the chemical composition of particulate matter extracted from anthracotic tissue (APE) and its effects on human bronchial cells (BEAS-2B) and lung adenocarcinoma cells Leia mais…

Diagnóstico e monitoramento da descarga sólida em suspensão no Rio Juqueri, nas áreas do reservatório Paiva Castro, Mairiporã, São Paulo, SP

Abstract: This study presents a diagnosis and monitoring of suspended sediment load in the Paiva Castro reservoir watershed, Juqueri River, Mairiporã-SP, Brazil. Fieldwork was conducted from October 2023 to December 2024, encompassing 21 measurement and sampling campaigns. Five sediment monitoring stations were established along the Juqueri River. Flow measurements were Leia mais…

Encapsulation of Syrah red wine polyphenols by nano spray dryer

Abstract: This study aimed to develop nanoparticles containing polyphenols from Syrah red wine grapes to protect the bioactive compounds and improve their stability and bioavailability. The properties of maltodextrin (MD) and gum arabic (GA), used as encapsulating agents, were evaluated. The coating material formulation was conducted in a completely randomized Leia mais…

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