Abstract:
This study investigates the influence of different polymorphs and concentrations of niobium pentoxide (Nb₂O₅) on the aging resistance and cytotoxicity of Y₂O₃-stabilized zirconia (ZrO₂) bioceramics. The goal was toevaluate the structural, mechanical, and biological responses of ZrO₂–Y₂O₃–Nb₂O₅ systems, addressing concerns related to low-temperature degradation (LTD) in biomedical applications. Different polymorphs of Nb₂O₅ (monoclinic,orthorhombic, and mixtures) were incorporated at various concentrations (1–26 wt%) into 3 mol% Y₂O₃-stabilized ZrO₂ and processed through controlledsintering cycles. Phase compositions were characterized by X-ray diffraction and Raman spectroscopy. Mechanical and microstructural properties were evaluated through density measurements, Vickers microhardness, flexural strength testing, and SEM imaging. Accelerated aging tests simulated long-term in vivo conditions, and cytotoxicity was assessed via in vitro assaysusing L929 fibroblast cells in accordance with ISO 10993-5. Results demonstrated that the addition of 1 wt% monoclinic Nb₂O₅ maintained structural integrity, mechanical strength, and biocompatibility, while higher concentrations led to cracking and tetragonal phase destabilization. Aging ledto a moderate reduction in mechanical strength, and no cytotoxic effects wereobserved. The findings suggest that low-level monoclinic Nb₂O₅ doping mayenhance ZrO₂’s viability for biomedical use.
Referência:
PAIVA, Julio Carvalho; LEO, Patricia; FREDERICCI, Cátia; BUENO, Luciano Avallone. Effect of Nb2O5 on the aging and cytotoxicity of ZrO2-Y2O3 based biomaterial. International Jornal Of Advances in Medical Biotechnology, v.8, n.1, 1-19, May, 2026.
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