Rifampicin nanoprecipitation using flow focusing microfluidic device


We present the nanoprecipitation of rifampicin performed device as a means to reduce the particle size and enhance the dissolution rate. The microfluidic device was microfabricated in glass substrate with a 45º flow-focusing geometry. The dimensions of the central and side channels are 100 µm and 110 µm in width, respectively, and 85 µm in depth. We analyze the influence of different parameters in the rifampicin particles size, such as: rifampicin concentration, the presence of surfactant, the total fluid flow and solvent to anti-solvent flow rate ratio. The processed rifampicin was evaluated not only in terms of size, but also morphology, crystallinity, thermal characteristics and dissolution rate. We produce particle sizes in a controlled manner with sizes ranging from 100nm to 1.2 µm. The particles present an amorphous profile and enhanced dissolution rate as compared to commercial raw rifampicin. These results are promising and have enabled us to better understand the rifampicin self-assembly process in microfluidic device.

SCHIANTI, Juliana de Novais; CERIZE, Natália Neto Pereira; OLIVEIRA, Adriano Marim de; DERENZO, Silas; SEABRA, Antônio C.; GÓNGORA-RÚBIO, Mário Ricardo. Rifampicin nanoprecipitation using flow focusing microfluidic device. Journal of Nanomedicine and Nanotechnology, v. 4, n. 3, p. 1-6, 2013.

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