Abstract:
Nanoparticulate materials have increased its applications in commercial products, mainly cosmetic. Polymeric nanoparticle to be used as carrier substance must have suitable chemical and physical properties and does not induce toxic reactions. Poly(methyl methacrylate) (PMMA) and polystyrene (PSty) are polymers with a potential to be used in the preparation of nanoparticles and used as a carrier system for drug delivery. This requires a better understanding of the interaction of these polymers with different organisms. In this study, the cytotoxicity and phototoxicity profile of the PMMA and PSty nanoparticles loaded with sunscreen agents, as 3-benzophenone (BZ-3) and octyl methoxycinnamate (OMC), on murine fibroblasts cells were measured by standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and neutral red uptake assay. PMMA nanoparticles were also evaluated by morphological transformation assay. The results showed that the PMMA and PSty nanoparticles are nontoxic and could be useful for various in-vivo and in-vitro biomedical applications.
Reference:
LÉO, Patrícia; CERIZE, Natália Neto Pereira; FEITOSA, L.O.; GAVIOLI, Renato Rosafa; GOIS, Romário de Souza; MIRANDA, Beatriz Nogueira Messias de; OLIVEIRA, Adriano Marim de. In-vitro cytotoxicity of nanoencapsulated sunscreen agents obtained by pickering by pickering emulsion polymerization. International Journal of Pharmacy & Pharmaceutical Research, v.12, n.3, p.1-13, jun., 2018.
Access to the article in the newspaper site:
http://ijppr.humanjournals.com/wp-content/uploads/2018/07/1.-P.-Leo-N.-N.-P.-Cerize-L.-O.-Feitosa-R.-Gavioli-R.-de-S.-Gois-B.-N.-M.-Miranda-A.-M.-Oliveira.pdf
Nanoparticulate materials have increased its applications in commercial products, mainly cosmetic. Polymeric nanoparticle to be used as carrier substance must have suitable chemical and physical properties and does not induce toxic reactions. Poly(methyl methacrylate) (PMMA) and polystyrene (PSty) are polymers with a potential to be used in the preparation of nanoparticles and used as a carrier system for drug delivery. This requires a better understanding of the interaction of these polymers with different organisms. In this study, the cytotoxicity and phototoxicity profile of the PMMA and PSty nanoparticles loaded with sunscreen agents, as 3-benzophenone (BZ-3) and octyl methoxycinnamate (OMC), on murine fibroblasts cells were measured by standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and neutral red uptake assay. PMMA nanoparticles were also evaluated by morphological transformation assay. The results showed that the PMMA and PSty nanoparticles are nontoxic and could be useful for various in-vivo and in-vitro biomedical applications.
Reference:
LÉO, Patrícia; CERIZE, Natália Neto Pereira; FEITOSA, L.O.; GAVIOLI, Renato Rosafa; GOIS, Romário de Souza; MIRANDA, Beatriz Nogueira Messias de; OLIVEIRA, Adriano Marim de. In-vitro cytotoxicity of nanoencapsulated sunscreen agents obtained by pickering by pickering emulsion polymerization. International Journal of Pharmacy & Pharmaceutical Research, v.12, n.3, p.1-13, jun., 2018.
Access to the article in the newspaper site:
http://ijppr.humanjournals.com/wp-content/uploads/2018/07/1.-P.-Leo-N.-N.-P.-Cerize-L.-O.-Feitosa-R.-Gavioli-R.-de-S.-Gois-B.-N.-M.-Miranda-A.-M.-Oliveira.pdf
