Abstract:
The caffeine is a drug widely used in the treatment of cellulite. This work developed new controlled release systems of caffeine using functional polymers (chitosan and acrylates copolymer) and the nanoclay montmorillonite and evaluated the release profile of these systems. It were developed six controlled release systems evaluated concerning the use of temperature, presence of functional polymer and type of coating. All the systems were dry in a mini Spray Dryer B-290 Buchi® and the in vitro release profile was analyzed in acetate buffer pH 5.0 with 0.5% of PEG-80 Sorbitan Laurate, during 5 hours, using a dialysis membrane previous hydrated. It was observed that the systems containing chitosan presents a faster release of caffeine when compared with the acrylate systems and nanoclay. The presence of acrylates copolymer promote a better performance in the control of the release of caffeine when prepared with heating. All the samples shown a slower release than the free drug evidencing an adsorption of the caffeine in the clay layers.
Reference:
BALOGH, Tatiana Santana; TUNUSSI, Ariane Simões; CERIZE, Natália Neto Pereira; ALDEIA, Wagner; OLIVEIRA, Adriano Marim de. Development of controlled realease systems of caffeine using hybrid systems functional polymer and anoclay for cellulite treatment. In: IFSCC CONGRESS, 28., 2014, Paris. Work Presented.
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The caffeine is a drug widely used in the treatment of cellulite. This work developed new controlled release systems of caffeine using functional polymers (chitosan and acrylates copolymer) and the nanoclay montmorillonite and evaluated the release profile of these systems. It were developed six controlled release systems evaluated concerning the use of temperature, presence of functional polymer and type of coating. All the systems were dry in a mini Spray Dryer B-290 Buchi® and the in vitro release profile was analyzed in acetate buffer pH 5.0 with 0.5% of PEG-80 Sorbitan Laurate, during 5 hours, using a dialysis membrane previous hydrated. It was observed that the systems containing chitosan presents a faster release of caffeine when compared with the acrylate systems and nanoclay. The presence of acrylates copolymer promote a better performance in the control of the release of caffeine when prepared with heating. All the samples shown a slower release than the free drug evidencing an adsorption of the caffeine in the clay layers.
Reference:
BALOGH, Tatiana Santana; TUNUSSI, Ariane Simões; CERIZE, Natália Neto Pereira; ALDEIA, Wagner; OLIVEIRA, Adriano Marim de. Development of controlled realease systems of caffeine using hybrid systems functional polymer and anoclay for cellulite treatment. In: IFSCC CONGRESS, 28., 2014, Paris. Work Presented.
Log in to the Library/IPT-DAIT to access the PDF text. (Document is password protected, ask Customer Service/Library-DAIT/IPT:
escriba.ipt.br/pdf_restrito/172663.pdf
